Bioactive Small Molecules
Cayman Chemical ANTIBODY TAS 0728 25mg
A covalent HER2 inhibitor (IC50 = 36 nM); selective for HER2 over panels of 386 and 374 additional kinases, as well as a panel of 68 non-kinase enzymes, at 1 µM; inhibits HER2 autophosphorylation in HER2-overexpressing SK-BR-3 cells; inhibits the growth of six HER2-amplified cancer cell lines (GI50s = 1.6-31 nM); reduces tumor volume in NCI N87 and BT474 mouse xenograft models
STEMCELL Technologies Tamoxifen, Size: 10 g
Tamoxifen is a selective estrogen receptor modulator (SERM), with tissue-specific antagonistic or agonistic effects. Receptor activation leads to the formation of homo- and hetero-dimers, which in turn interact with accessory proteins to regulate gene transcription. Tamoxifen is commonly used to activate Cre-ER in transgenic conditional models.CELL LINE DEVELOPMENT· Used in transgenic models to induce Cre-mediated recombination in conjunction with Cre-ER, a fusion protein consisting of Cre recombinase and a mutant form of the estrogen receptor hormone-binding domain that specifically binds tamoxifen but not estrogen (Feil et al.; Zhang et al.). CANCER RESEARCH· Inhibits growth in the human breast cancer cell line, MCF-7 (Katzenellenbogen et al.).· Antagonist of estrogen receptor action in breast tissue and breast cancer cells (Abe et al.; Horwitz et al.).
Medchemexpress LLC IM-54 | 861891-50-1 | 99.3% | 325.40 | 50 MG
IM-54 is a selective inhibitor of oxidative stress-induced necrosis. It demonstrates potent inhibitory activity against H2O2-induced necrosis. IM-54 acts as a potential cardioprotective agent and a biological tool for investigating the molecular mechanisms of cell death.
- Selective inhibitor of oxidative stress-induced necrosis.
- Potent inhibitory activity against H2O2-induced necrosis.
- Potential cardioprotective agent.
- Biological tool for investigating the molecular mechanisms of cell death.
Medchemexpress LLC Betamipron | 3440-28-6 | 98.7% | 500 MG
Betamipron is a chemical compound which is used together with Panipenem to inhibit Panipenem uptake into the renal tubule and prevent nephrotoxicity.
- Used in conjunction with Panipenem
- Inhibits Panipenem uptake into renal tubule
- Prevents nephrotoxicity
- Targets bacteria
- Functions as an antibiotic
- Part of anti-infection pathway
Cayman Chemical CAY10576 Inhibitors
A multi-kinase inhibitor; inhibits TBK1, Plk1, and IKKβ (IC50s =0.093, 0.63, and 0.79 µM, respectively) and is selective for these kinases over IKKε, Aurora B kinase, and Cdk2 (IC50s = 5, >5.32 and >30 µM, respectively); inhibits ROCK1 and ROCK2 (IC50s = 1.8 and 0.04 µM, respectively)
Cayman Chemical NG NGdImethylLArgInInhy 25mg
An endogenous NOS inhibitor; levels are increased in Dahl salt-sensitive rats fed a high-salt diet concomittant with an increase in blood pressure
Medchemexpress LLC Biocytin hydrazide | 102743-85-1 | MFCD00133143 | 99.2% | C16H30N6O3S | 10MG
Biocytin hydrazide is a biotin-containing hydrazide reagent used to label glycoconjugates. It selectively reacts with oxidized sugar residues to introduce a biotin tag for detection by avidin-biotin methods and is supplied for research use.
- Selectively labels sialic acids, galactose, and other aldehyde-containing sugars.
- Introduces a biotin tag for detection with avidin-biotin methods.
- Water-soluble and compatible with aldehyde fixation for microscopy.
- Suitable for biochemical assays and histochemical glycoprotein detection.
- Supplied in small research-use quantities for laboratory experiments.
- High purity supports consistent labeling performance.
Medchemexpress LLC Rig012 | 2642218-43-5 | ≥99.0% | C23H21NO3 | 10MG
RIG012 is a small-molecule antagonist of the RIG-I innate immune receptor. It inhibits RIG-I ATPase activity (IC50 = 0.71 μM, NADH-coupled ATPase assay) and suppresses downstream signaling, including interferon-β and ISG expression. Supplied as a research-grade solid for in vitro studies; not for human or diagnostic use.
- Potent RIG-I inhibition (IC50 0.71 μM).
- Activity measured by NADH-coupled ATPase assay.
- Suppresses IFN-β and ISG expression in cellular assays.
- Supplied as a purified small-molecule for research use.
- Product datasheet and safety data sheet available for handling information.
- Useful for studying innate immune signaling and antiviral responses.
Medchemexpress LLC Trametinib (DMSO solvate) | 1187431-43-1 | MFCD21609250 | 99.6% | 693.53 g/mol | C28H29FIN5O5S | 5 MG
Trametinib (DMSO solvate) is a potent, selective MEK1/2 inhibitor supplied as a DMSO solvate crystalline powder for research use. It is characterized for in vitro and in vivo applications with documented solubility and storage conditions; handle and formulate according to supplier guidance.
- Potent, selective MEK1/2 inhibition for signaling pathway studies.
- Supplied as a DMSO solvate crystalline powder for stability.
- Soluble in DMSO at approximately 3.33 mg/mL (4.80 mM); may require sonication.
- Formulations for in vivo use achievable at ≥ 2.5 mg/mL in common vehicles.
- Storage: powder stable at -20°C (3 years) or 4°C (2 years); solutions require low-temperature storage.
- Characterized by CAS 1187431-43-1, formula C28H29FIN5O5S, molecular weight 693.53.
Cayman Chemical ANTIBODY A-769662 5mg
A direct activator of AMPK (EC50 = 116 nM in a cell-free assay); allosterically activates AMPK and inhibits its dephosphorylation on Thr172; activates β1 subunit-containing AMPK heterotrimers; has been used to stimulate CYP450-mediated fatty acid oxidation, inhibit adipocyte differentiation, explore glucose uptake in skeletal muscle, and promote endothelial cell survival during metabolic stress
Cayman Chemical ANTIBODY VU0155069 10mg
A potent and selective inhibitor of PLD1, both in vitro (IC50 = 46 nM) and in cells (IC50 = 11 nM); also effective as a PLD2 inhibitor at higher concentrations (IC50 = 933 nM in vitro; 1,800 nM in cells); strongly inhibits the invasive migration of several breast cancer cell lines in trans well assays
Cayman Chemical ANTIBODY 11 R-HEDE 25ug
A mono hydroxy fatty acid derived from of 11Z,14Z-eicosadienoic acid in an LO-type reaction catalyzed by COX; spectrophotometric measurement of the conjugated diene is occasionally used to quantify COX activity
Cayman Chemical ANTIBODY5 6-EET 25UG
A racemic version of a CYP450 metabolite of arachidonic acid; provided as a mixture of free acid and lactone; inhibits Cav3 channels (IC50 = 0.54 µM for Cav3.2); decreases nifedipine-resistant phenylephrine-induced vasoconstriction in isolated mouse mesenteric arteries via Cav3.2 blockade at 3 µM; a substrate of COX-1 and COX-2 in oxygen consumption and product formation assays at 50 µM